Abstract: 2000 minority residents in Guizhou were investigated by means of the brief Subjective Well-Being Scale for Chinese Citizens(SWBS-CC20), Social Support Rating Scale(SSRS), and self-designed questionnaires about Social Mental Stress of the minority residents. Significant difference is found in the SWB of the minority residents in Guizhou in aspects like their income, place of residence(urban or rural), education and marital status. There exists a significant positive correlation in between the total score of the SWB of the minority residents and the total score of social support, between the subjective support, objective support and support use degree; and a significantly negative correlation is found in between the total score of SWB of minority residents and their culture marriage pressure, family life press, health and security pressure, and social pressure. Subjective support, objective support and support use degree are a positive predictor of the SWB; while the culture marriage press, family life press and social press plays a role of a negative predictor.