Abstract: Taking the 11 provinces and cities of the Yangtze River Economic Belt as the research object from 2011 to 2023, we analyze the synergistic evolution of the spatio-temporal characteristics of the two with the help of the Harken model and the Dagum Gini coefficient, and use the panel grey correlation model to reveal their influencing factors. It is found that:1)The overall integrated value of cultural and tourism integration and economic resilience of the Yangtze River Economic Belt is steadily increasing, and the difference between upstream and downstream is significant. 2)Economic resilience is the leading parameter in the evolution of the Yangtze River Economic Belt. The overall synergistic evolution goes through the stage of "slow rise-acceleration", and the system disorder is concentrated in the upstream area.3)Inter-regional differences are the main source of significant spatial differences in the synergy values of the two systems. 4)The synergistic development of cultural and tourism integration and economic resilience in the Yangtze River Economic Belt is affected by the proportion of employment in the cultural, sports and entertainment industry, per capita tourism income, cultural and entertainment consumption, and Internet penetration rate in decreasing order, and each factor has obvious spatial heterogeneity in the synergistic value of the region.