Abstract: Based on the data of population, industry and land from 2010 to 2020, the spatial-temporal pattern and driving mechanism of coordinated development of population-industry-land urbanization in central Guizhou urban agglomeration were analyzed by aid of coupling degree model, partial least squares regression model and geographical weighted regression model. The results showed that: ① the urbanization rate of land in central Guizhou urban agglomeration saw an obvious increase, the level of population urbanization increased steadily, and the development of industry urbanization was slow, industries are the primary driving force for urbanization development, yet the quality of industry urbanization was not high, and population agglomeration and urbanization bring inadequate driving force. ② Although the coordination level of urbanization is generally low, it takes on an upward trend as time goes on, and the coordination level is chiefly on the verge of maladjustment or mild maladjustment; The change of coordination degree shows the evolving characteristics of "slight increase plus drastic increase", with the coordination degree in the central part rising rather significantly and the coordination degree in the northwest part rising too slowly. ③ The spatial differentiation of urbanization coordination level is significant, showing an obvious high-value agglomeration area centered on Guiyang, but the gap between counties tends to converge. ④ Road network density, per capita net income of farmers, investment intensity per unit area, average years of education and population migration rate have significant effects on the coordinated development of urbanization in counties, featuring a strong spatial-temporal differentiation law.