Abstract: In order to enhance the practice teaching of the tourism management major, teacher-student studio through school-enterprise cooperation is set up on the basis of modern apprenticeship to conduct the reform and innovation of the practice teaching mode.Taking the business skills and abilities training of travel agency as an example, the “four in one”studio practice teaching mode which involves combination of“training studios and travel agencies, practical training projects and business projects, vocational students and corporate employees, instructors, and business experts”has been constructed.The mode adopts a mufti-dimensional and coordinated operating mechanism, which solves the crucial problems in practice teaching, bringing into full play the advantages of school-enterprise cooperation, working-learning coupling, and integration of production and education so as to enhance the students’ professional skills and practical ability.For the implementation of this model, the development strategy is proposed.