Abstract: Based on the relevant theories of social network, the influence of high-tech industrial clusters network in Yangtze river delta on regional innovation is put under examination.All of the 28 national high-tech industry parks in Yangtze river delta were selected as the research sample, with the research results by Lilin as the frame of reference (2014) , an industrial clusters network was constructed based on the dominant industries commonly found in these industry parks.Then by use of Ucinet Software, aquantitative and visual analysis was made of the innovation network.The results showed that the overall density of high-tech industrial innovation network is regretfully low.The number of structural holes in individual areas and industries is too small.There exists an obvious core-edge structure in the innovation network of high-tech industrial clusters in the Yangtze river delta.According to the research results of the cluster innovation network, it is believed that local governments should actively improve the network relations.Efforts should be made to enhance the innovative capacity through the elevation of the overall network density and regional centralization degree;by means of attracting foreign investment and enterprises, the structural hole limitation of innovation network is to be eliminated, and the innovation efficiency of cluster network be improved.