Abstract: The pectin was extracted from the Shaxi honey pomelo peel by ultrasonic-assisted cellulase. The influence of the solid-liquid ratio, enzyme dosage, enzymolysis time, enzymolysis temperature, extracting pH value, ultrasonic power, ultrasonic extracting time, extracting temperature, on the yield of the pectin, were investigated. The optimal extracting technological conditions were determined by orthogonal experiments, which were listed as followed: the enzyme dosage of 15 U/ml, solid-liquid of 1:35, ultrasonic time of 70 min, and the ultrasonic power of 320 W. Under the optimal conditions, the yield of pectin was 20.2%; the galacturonic acid content of the product was 83.8%; the esterification degree was 61.6%; the moisture content was 6.2%; the content of the water-insoluble ash was 2.44%; and the content of acid-insoluble ash was 0.29%.